As others have apparently reported, I've also encountered the spinning wheel when clicking, or when hovering over the hotspots on a JA Image HotSpot module that is working perfectly on the Joomla 3.x version of the site. I'm using the latest download of your code and this test site is running Joomla 4.1 under PHP 8.0 FCGI.
The pop-ups all show up in the correct locations, but the selected images never load. Only the spinning wheel. I'm seeing the same issue on different browsers and on Android mobile. I've also tried using loadpostion and the template fixed bottom position with no change in what is happening.
Here is hoping that there is a quick fix. Thank you!